Management of primary sclerosing cholangitis

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Primary sclerosing cholangitis: diagnostic and management challenges

Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease affecting intra- and extrahepatic bile ducts, primarily the large biliary ducts. Clinical manifestations are broad, and the spectrum encompasses asymptomatic cholestasis, icteric cholangitis with pruritis, cirrhosis, and cholangiocarcinoma. Though rare, PSC has a propensity to affect young to middle-aged males and is stro...

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Primary sclerosing cholangitis: etiopathogenesis and clinical management.

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease characterized by the destruction of medium to large-sized bile ducts and intense, concentric fibrosis. Complications from PSC include bacterial cholangitis, cirrhosis, and cholangiocarcinoma and a therapy that might alter the natural history of the disease remains lacking. Our understanding of the pathogenesis of PSC a...

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Improving Symptoms of Primary Sclerosing Cholangitis by Iranian Traditional Medicine

Introduction: Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease that results from the inflammation and destruction of intra- and extra-hepatic bile ducts and fibrosis which can lead to cirrhosis. The purpose of this report is to provide the clinical experience of Iranian traditional medicine with the best therapeutic effect within the shortest time. <s...

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Primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a chronic inflammatory disorder of the biliary system that results in progressive fibrosis and strictures of the intrahepatic and extrahepatic bile ducts. Typical radiological changes on retrograde cholangiography are shown in Figure 1. These strictures cause cholestatic liver disease that may progress to end-stage cirrhosis. The disorder has a strong ass...

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Primary Sclerosing Cholangitis: Introduction

The prevalence of primary sclerosing cholangitis in the United States is approximately 1–6 cases per 100,000 population. Most patients with primary sclerosing cholangitis are men (75%) with an average age of approximately 40 years at diagnosis. The overwhelming majority of patients affected with primary sclerosing cholangitis are Caucasian. The etiology is unknown but current opinion favors an ...

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ژورنال

عنوان ژورنال: World Journal of Hepatology

سال: 2011

ISSN: 1948-5182

DOI: 10.4254/wjh.v3.i6.137